Metabolic Reprogramming: Strategy for Ischemic Stroke Treatment by Ischemic Preconditioning.
Jing Liang1, Rongrong Han1, Bing Zhou1,2
1Beijing Advanced Innovation Center for Big Data-Based Precision Medicine, Interdisciplinary Innovation Institute of Medicine and Engineering, Beihang University, Beijing 100191, China.
Biology
|June 2, 2021
Summary
Ischemic preconditioning (IPC) protects the brain against stroke by regulating metabolic reprogramming. This review details how IPC maintains brain energy and redox balance, crucial for neuroprotection during ischemic events.
Area of Science:
- Neuroscience
- Metabolism
- Stroke Research
Background:
- Stroke is a major global cause of death and disability.
- Ischemic preconditioning (IPC) shows neuroprotective potential against stroke.
- IPC's precise neuroprotective mechanisms require further elucidation.
Purpose of the Study:
- To review metabolic disorders and plasticity in ischemic stroke.
- To explore how IPC utilizes metabolic reprogramming for neuroprotection.
- To highlight IPC's role in maintaining brain homeostasis during stroke.
Main Methods:
- Literature review of metabolic reprogramming in stroke.
- Analysis of IPC's impact on brain metabolism.
- Synthesis of findings on energy and redox homeostasis.
Main Results:
- Metabolic reprogramming is key in stroke pathogenesis and progression.
- IPC actively engages metabolic pathways to counteract stroke-induced damage.
- IPC ensures energy and redox balance, preserving brain function.
Conclusions:
- Understanding metabolic reprogramming is vital for stroke treatment.
- IPC offers a promising endogenous strategy for stroke prevention and treatment.
- Targeting metabolic pathways could enhance IPC's neuroprotective effects.
