Non-Enzymatic Glucose Biosensor Based on Highly Pure TiO₂ Nanoparticles.

Area of Science:

• Materials Science
• Electrochemistry
• Biosensors

Background:

• Development of non-enzymatic glucose sensors is crucial for diabetes management.
• Titanium dioxide (TiO2) nanoparticles offer promising properties for electrochemical applications.
• Conductive polymers like chitosan-polypyrrole (CS-PPy) enhance sensor performance.

Purpose of the Study:

• To fabricate a novel non-enzymatic glucose biosensor.
• To utilize high-purity TiO2 nanoparticles synthesized via thermal plasma.
• To integrate CS-PPy conductive polymer films for improved sensing capabilities.

Main Methods:

• Synthesis of TiO2 nanoparticles using thermal plasma.
• Electrochemical deposition of CS-PPy films on TiO2-coated substrates.
• Characterization using X-ray diffraction (XRD), dynamic light scattering (DLS), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM).
• Glucose detection analysis via cyclic voltammetry (CV).

Main Results:

• The CS-PPy/TiO2 biosensor exhibited high sensitivity (302.0 µA mM⁻¹ cm⁻² with R² = 0.9957).
• A low detection limit of 6.7 μM for glucose was achieved.
• The biosensor demonstrated excellent selectivity and reactivity.

Conclusions:

• The fabricated CS-PPy/TiO2 biosensor is a viable non-enzymatic glucose sensing platform.
• The synthesis method and material integration result in a highly sensitive and reliable device.
• This approach offers an easily manufactured and effective solution for glucose monitoring.