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Updated: Nov 3, 2025
14:57
Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
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The Role of p53 Dysfunction in Colorectal Cancer and Its Implication for Therapy
Maurice Michel1, Leonard Kaps1,2, Annett Maderer1
1I. Department of Medicine, University Medical Center Mainz, 55131 Mainz, Germany.
Cancers
|June 2, 2021
Summary
Mutations in the TP53 gene are common in colorectal cancer (CRC), impacting treatment response. These TP53 mutations may enhance immunotherapy effectiveness by increasing tumor neoantigens.
Area of Science:
- Oncology
- Molecular Biology
- Cancer Genetics
Background:
- Colorectal cancer (CRC) is a leading cause of cancer-related deaths globally.
- CRC development involves the stepwise accumulation of genetic mutations, activating oncogenes and deactivating tumor suppressor genes.
- Key genes involved include KRAS, TP53, and APC, driving the progression from adenoma to adenocarcinoma.
Purpose of the Study:
- To review the significant implications of TP53 mutations in colorectal cancer.
- To explore how TP53 mutations influence therapeutic strategies and treatment outcomes.
- To discuss the role of TP53 in personalized medicine approaches for CRC.
Main Methods:
- This review synthesizes current research on TP53 gene mutations in CRC.
- It examines the molecular mechanisms underlying p53 dysfunction in cancer cells.
- The analysis includes the impact of p53 on the tumor microenvironment and immune response.
Main Results:
- TP53 mutations can lead to resistance to conventional chemotherapy.
- Conversely, p53-mutated tumors exhibit increased neoantigen presentation, making them potentially more responsive to immunotherapy.
- Aberrant p53 function affects tumor microenvironment components, including cancer-associated fibroblasts, influencing tumor progression through p53-mediated signaling.
Conclusions:
- TP53 mutations present a dual role in colorectal cancer, affecting both chemotherapy resistance and immunotherapy potential.
- Understanding p53 status is crucial for tailoring effective treatment strategies and advancing personalized medicine in CRC.
- Targeting p53-related pathways and the tumor microenvironment offers promising avenues for novel CRC therapies.
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