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Updated: Nov 3, 2025

Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS
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Immunosuppressive Effects of Myeloid-Derived Suppressor Cells in Cancer and Immunotherapy

Mithunah Krishnamoorthy1,2, Lara Gerhardt1,2, Saman Maleki Vareki1,2,3

  • 1Cancer Research Laboratory Program, Lawson Health Research Institute, London, ON N6A5 W9, Canada.

Cells
|June 2, 2021
PubMed

The primary function of myeloid cells is to protect the host from infections. However, during cancer progression or states of chronic inflammation, these cells develop into myeloid-derived suppressor cells (MDSCs) that play a prominent role in suppressing anti-tumor immunity. Overcoming the suppressive effects of MDSCs is a major hurdle in cancer immunotherapy. Therefore, understanding the mechanisms by which MDSCs promote tumor growth is essential for improving current immunotherapies and developing new ones. This review explores mechanisms by which MDSCs suppress T-cell immunity and how this impacts the efficacy of commonly used immunotherapies.

Keywords:
MDSCsT-cellsanti-PD-1cancerimmunotherapytumors

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