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Characterizing Extracellular Vesicles from Biological Fluids
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Extracellular Vesicles from Plants: Current Knowledge and Open Questions.

Ornella Urzì1, Stefania Raimondo1, Riccardo Alessandro1,2

  • 1Department of Biomedicine, Neuroscience and Advanced Diagnostics (Bi.N.D), Section of Biology and Genetics, University of Palermo, 90133 Palermo, Italy.

International Journal of Molecular Sciences
|June 2, 2021
PubMed
Summary
This summary is machine-generated.

Plant-derived extracellular vesicles (PDEVs) show therapeutic potential due to their complex composition. Research is advancing their isolation, characterization, and use as drug delivery systems.

Keywords:
anti-inflammatory effectsanti-tumor effectsdrug-delivery vehiclesomics characterizationplant-derived extracellular vesicles

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Area of Science:

  • Biotechnology
  • Natural Products
  • Cell Biology

Background:

  • Growing scientific interest in natural substances and extracellular vesicles (EVs) from various organisms.
  • Increasing focus on isolating and characterizing plant-derived extracellular vesicles (PDEVs) and their therapeutic potential.

Purpose of the Study:

  • To review current knowledge on PDEVs, covering isolation, content characterization, biological properties, and drug delivery applications.
  • To highlight areas of controversy and future research directions for PDEVs.

Main Methods:

  • Literature review of studies on plant-derived extracellular vesicles.
  • Discussion of isolation techniques and characterization methods for PDEVs.
  • Analysis of biological properties and therapeutic applications of PDEVs.

Main Results:

  • PDEVs, similar to animal EVs, contain small RNAs, proteins, lipids, and metabolites.
  • The complex composition of PDEVs makes them attractive for therapeutic applications.
  • PDEVs have potential applications as drug delivery systems.

Conclusions:

  • PDEVs represent a promising area of research with significant therapeutic potential.
  • Further research is needed to address controversial issues and optimize the use of PDEVs.
  • Focus on isolation, characterization, and application of PDEVs is crucial for future advancements.