Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Investigating video consultations as a new form of care for neuropalliative patients in specialized outpatient care: results from the project TANNE (telemedical answers to neurological inquires in real time).

Frontiers in neurology·2026
Same author

Polymer Replicas of Fs-Laser-Induced Periodic Surface Structures for Cell Attachment.

Materials (Basel, Switzerland)·2026
Same author

Electrosensitivity in planthoppers (Insecta: Hemiptera: Auchenorrhyncha: Fulgoromorpha).

Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology·2026
Same author

Insights into the Corrosion Behavior of Pure Magnesium and Magnesium-Calcium Alloy (Mg-1.8 at.% Ca) in Thin-Film and Bulk Forms.

Materials (Basel, Switzerland)·2025
Same author

Investigating the surface topography of human acellular and cellular tooth cementum by atomic force microscopy.

Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft·2025
Same author

Simulating the Effect of Removing Circulating Tumor Cells (CTCs) from Blood Reveals That Only Implantable Devices Can Significantly Reduce Metastatic Burden of Patients.

Cancers·2024

Related Experiment Video

Updated: Nov 3, 2025

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
04:16

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants

Published on: August 5, 2021

2.5K

Femtosecond Laser-Processing of Pre-Anodized Ti-Based Bone Implants for Cell-Repellent Functionalization.

Martina Muck1, Benedikt Wolfsjäger1, Karoline Seibert2

  • 1Institute of Applied Physics, Johannes Kepler University Linz, Altenberger Strasse 69, 4040 Linz, Austria.

Nanomaterials (Basel, Switzerland)
|June 2, 2021
PubMed
Summary

Researchers explored laser-induced nanostructures on titanium implants to reduce bone-forming cell adhesion. Optimal results were achieved on pre-anodized surfaces, suggesting potential for implants that minimize osteoblast adhesion.

Keywords:
cell activationcell-repellent surfaceslaser-induced microstructures and nanostructuresmedical implantsultrafast laser-processing

More Related Videos

Plasma Polishing as a New Polishing Option to Reduce the Surface Roughness of Porous Titanium Alloy for 3D Printing
06:12

Plasma Polishing as a New Polishing Option to Reduce the Surface Roughness of Porous Titanium Alloy for 3D Printing

Published on: April 28, 2023

2.0K
In Vitro Evaluation of The Effects Of Er,Cr:YSGG and Diode Lasers Used on Titanium Cylinder
07:05

In Vitro Evaluation of The Effects Of Er,Cr:YSGG and Diode Lasers Used on Titanium Cylinder

Published on: June 6, 2025

260

Related Experiment Videos

Last Updated: Nov 3, 2025

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants
04:16

Platelet-Derived Extracellular Vesicle Functionalization of Ti Implants

Published on: August 5, 2021

2.5K
Plasma Polishing as a New Polishing Option to Reduce the Surface Roughness of Porous Titanium Alloy for 3D Printing
06:12

Plasma Polishing as a New Polishing Option to Reduce the Surface Roughness of Porous Titanium Alloy for 3D Printing

Published on: April 28, 2023

2.0K
In Vitro Evaluation of The Effects Of Er,Cr:YSGG and Diode Lasers Used on Titanium Cylinder
07:05

In Vitro Evaluation of The Effects Of Er,Cr:YSGG and Diode Lasers Used on Titanium Cylinder

Published on: June 6, 2025

260

Area of Science:

  • Biomaterials Engineering
  • Surface Science
  • Cell Biology

Background:

  • Micro/nanostructures can reduce cell adhesion on implant materials.
  • Titanium alloys (Ti-6Al-4V) are common orthopedic implant materials.
  • Controlling cell adhesion is crucial for implant success.

Purpose of the Study:

  • To fabricate laser-induced hierarchical micro/nanostructures on Ti-6Al-4V.
  • To reduce bone-forming cell (osteoblast) adhesion using surface modifications.
  • To evaluate the impact of femtosecond laser processing and anodization on osteoblast behavior.

Main Methods:

  • Femtosecond laser treatment (1040 nm, 350 fs) to create surface structures.
  • Electrochemical anodization for surface chemistry modification.
  • Culturing human osteoblasts (SAOS-2) on treated Ti-6Al-4V samples (plates and bone screws) for 2-3 weeks.
  • Scanning Electron Microscopy (SEM) for cell characterization.

Main Results:

  • Femtosecond laser processing alone or combined with anodization activated osteoblasts, increasing extracellular matrix production.
  • Significant reduction in osteoblast adhesion was achieved only on pre-anodized surfaces.
  • Surface functionalization via femtosecond laser processing can create bone screws that inhibit osteoblast adhesion.

Conclusions:

  • Surface modification strategies need to be tailored for specific cell types.
  • Pre-anodization followed by femtosecond laser treatment is effective in reducing osteoblast adhesion.
  • This approach offers potential for developing orthopedic implants that minimize unwanted cell adhesion.