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Experimental atherosclerosis in goats.

P L Kaul1, M C Prasad

  • 1Division of Pathology, Indian Veterinary Research Institute, Uttar Pradesh.

Research in Veterinary Science
|May 1, 1988
PubMed
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Goats fed protected cholesterol developed aortic sudanophilia, similar to human atherosclerosis. This study suggests goats are a viable model for comparative atherosclerosis research.

Area of Science:

  • Cardiovascular Research
  • Animal Models in Atherosclerosis

Background:

  • Atherosclerosis is a significant human disease characterized by lipid deposition in arteries.
  • Developing reliable animal models is crucial for understanding atherosclerosis progression and testing interventions.

Purpose of the Study:

  • To evaluate the suitability of goats as an animal model for studying atherosclerosis.
  • To investigate the effects of dietary cholesterol on aortic pathology in goats.

Main Methods:

  • Nine experimental goats were fed 2 g of protected cholesterol daily for two, four, and nine months.
  • Aortic sudanophilia and intimal thickening were assessed.
  • Serum cholesterol levels were monitored.

Main Results:

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  • All goats developed aortic sudanophilia (5-75%), comparable to human fatty streaks/spots.
  • Serum cholesterol stabilized between 450-525 mg/100ml from month five.
  • Intimal thickening with foam cells was observed after four to nine months.

Conclusions:

  • Goats develop diet-induced aortic lesions similar to human atherosclerosis.
  • The degree of aortic sudanophilia correlated with hypercholesterolemia and feeding duration.
  • Goats represent a promising model for comparative atherosclerosis research.