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Viruses and Skin Cancer
Sara Becerril1, Roberto Corchado-Cobos2,3, Natalia García-Sancha2,3
1Department of Dermatology, Complejo Asistencial Universitario de Salamanca, Paseo San Vicente 58-182, 37007 Salamanca, Spain.
International Journal of Molecular Sciences
|June 2, 2021
Summary
This review highlights how viruses like human papillomavirus, Merkel cell polyomavirus, and human herpesvirus 8 are linked to skin cancers. Understanding these viral agents improves skin cancer prevention and treatment strategies.
Area of Science:
- Dermatology
- Virology
- Oncology
Background:
- Recent advancements in virology and skin cancer research have significantly impacted medical treatments.
- These discoveries offer new therapeutic and preventive options for patients with skin cancer.
- Our understanding of skin cancer biology has notably advanced due to these findings.
Purpose of the Study:
- To review viral agents implicated in various types of skin cancer, focusing on solid tumors.
- To examine the specific roles of human papillomavirus (HPV), Merkel cell polyomavirus (MCPyV), and human herpesvirus 8 (HHV-8).
Main Methods:
- Literature review of studies on viral oncogenesis and skin malignancies.
- Focused analysis on the association between specific viruses and distinct skin cancer types.
Main Results:
- Human papillomavirus is a key factor in squamous cell cancers.
- Merkel cell polyomavirus is etiologically linked to Merkel cell carcinoma.
- Human herpesvirus 8 is associated with the development of Kaposi's sarcoma.
Conclusions:
- Viral infections are significant contributors to the development of certain skin cancers.
- Identifying these viral links offers targeted approaches for diagnosis and therapy.
- Further research into virus-driven skin carcinogenesis can lead to improved patient outcomes.
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