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Controlling Capillary Flow Rate on Lateral Flow Test Substrates by Tape.

Zhiqing Xiao1, Yuqian Yang1, Xingwei Zhang2

  • 1Department of Biomedical Engineering, Shantou Univeristy, Shantou 515063, China.

Micromachines
|June 2, 2021
PubMed
Summary

Covering lateral flow test substrates with tape effectively controls liquid flow rate. This method decreases flow on nitrocellulose and significantly increases it on synthetic paper, improving test performance.

Keywords:
capillary flow ratelateral flow testsnitrocellulosesynthetic papertapevolume capacity

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Analytical Chemistry

Background:

  • Capillary flow rate is critical for lateral flow tests, impacting reagent interactions and reaction efficiency.
  • Optimizing flow dynamics is essential for enhancing the sensitivity and reliability of diagnostic assays.

Purpose of the Study:

  • To develop and evaluate a simple method for adjusting capillary flow rates on lateral flow test substrates using tape.
  • To investigate the effects of tape application on both traditional nitrocellulose and novel synthetic paper substrates.

Main Methods:

  • A tape-based method was applied to cover surfaces of nitrocellulose and synthetic paper (off-stoichiometry thiol-ene micropillars) lateral flow test substrates.
  • Capillary flow rates and volume capacities were measured before and after tape application.
  • The influence of tape length and placement on flow rate was analyzed for nitrocellulose.

Main Results:

  • Tape application reduced nitrocellulose flow rate to 61% of the original.
  • Synthetic paper exhibited a flow rate increase to at least 320% of the original, with enhanced volume capacity.
  • For nitrocellulose, longer tape and placement nearer the loading pad decreased flow rate.

Conclusions:

  • Taping surfaces offers a facile and effective strategy for modulating capillary flow in lateral flow tests.
  • This technique can be tailored to optimize flow characteristics for different substrate materials, potentially improving assay performance.
  • The findings provide valuable insights for designing and refining lateral flow test devices.