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Related Concept Videos

Immunoglobulin-like Cell Adhesion Molecules01:31

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Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
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Cell adhesion molecules (CAMs) are pivotal to multicellularity and the coordinated functioning of tissues and organ systems. They enable physical interactions between cells and provide mechanical strength to tissues. They also function as receptors for signal transmission across the plasma membrane. The CAMs are broadly classified into four families - integrins, cadherins, selectins, and immunoglobulin-like CAMs (IgCAMs).
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Related Experiment Video

Updated: Nov 3, 2025

A Murine Model of Fetal Exposure to Maternal Inflammation to Study the Effects of Acute Chorioamnionitis on Newborn Intestinal Development
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Perinatal Inflammation: Could Partial Blocking of Cell Adhesion Molecule Function Be a Solution?

Nikolaos Vrachnis1,2,3, Dimitrios Zygouris3, Dionysios Vrachnis4

  • 1Third Department of Obstetrics and Gynecology, School of Medicine, National and Kapodistrian University of Athens, Attikon Hospital, 11526 Athens, Greece.

Children (Basel, Switzerland)
|June 2, 2021
PubMed
Summary
This summary is machine-generated.

Blocking neonatal leukocyte adhesion molecules may treat inflammation. Understanding genetic leukocyte adhesion deficiencies (LAD) can guide antibody or peptide therapies for perinatal inflammation and infection in infants.

Keywords:
Ig superfamilycell adhesion moleculesintegrinsneonatal inflammationperinatalprenatalselectins

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Area of Science:

  • Neonatal immunology
  • Perinatal medicine
  • Molecular biology

Background:

  • Inflammation frequently causes organ injury and morbidity in neonates despite medical advances.
  • Neonatal vulnerability to infection is linked to impaired leukocyte adhesion, with decreased cell adhesion molecule expression reducing inflammatory response.
  • Integrins, selectins, and immunoglobulin superfamily molecules are crucial in the inflammatory cascade.

Purpose of the Study:

  • To consolidate knowledge on cell adhesion molecule function and genetic deficiencies (LAD I, II, III) in neonates.
  • To explore therapeutic potential of targeting cell adhesion molecules for neonatal inflammation.
  • To identify promising interventions for perinatal inflammation and infection.

Main Methods:

  • Review of current understanding of cell adhesion molecules in neonatal inflammation.
  • Analysis of genetic deficiencies, specifically leukocyte adhesion deficiency (LAD) types I, II, and III.
  • Exploration of potential therapeutic strategies including antibody therapy and small peptide inhibitors.

Main Results:

  • Cell adhesion molecules play a vital role in the neonatal inflammatory cascade.
  • Genetic deficiencies in these molecules, like LAD, cause severe symptoms in infants.
  • Targeting these molecules offers a potential therapeutic avenue.

Conclusions:

  • Intervention by blocking neonatal leukocyte cell adhesion molecule function shows promise for treating inflammation.
  • Antibody therapy targeting LAD in preterm and term infants is a promising perspective.
  • Combining small peptides for cellular adhesion inhibition could be a significant scientific advance.