Related Experiment Video
Updated: Nov 3, 2025
08:58
Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
12.5K
Nutritional Treatment in Crohn's Disease
Giacomo Caio1,2,3,4, Lisa Lungaro1,5, Fabio Caputo1,2,3,5
1Department of Translational Medicine, University of Ferrara, 44121 Ferrara, Italy.
Nutrients
|June 2, 2021
Summary
This review covers recent nutritional findings for Crohn
Area of Science:
- Gastroenterology and Nutrition
Background:
- Crohn's disease (CD) is a chronic inflammatory bowel disease (IBD) impacting the entire gastrointestinal tract.
- Malnutrition is prevalent in 65-75% of CD patients, underscoring the critical role of diet in disease management.
Purpose of the Study:
- To review the latest advancements in nutritional strategies for managing Crohn's disease.
- To explore established and novel dietary approaches, including emerging research in nutrigenomics.
Main Methods:
- Comprehensive literature review of recent findings in nutrition and Crohn's disease.
- Analysis of established dietary interventions and new nutritional theories.
- Inclusion of recent progress in research fields like nutrigenomics.
Main Results:
- Diet is a cornerstone in managing Crohn's disease, with significant impact on patient outcomes.
- Recent research expands beyond traditional diets to include personalized nutrition (nutrigenomics).
Conclusions:
- The review highlights the evolving landscape of nutritional science in Crohn's disease management.
- Integrating recent findings and novel approaches like nutrigenomics is crucial for optimizing patient care.
Keywords:
Crohn’s diseaseenteral nutritioninflammatory bowel diseaselow FODMAP dietnutrigenomicsparenteral nutritionspecific carbohydrate dietMore Related Videos
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
473
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
473
01:29Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents
299
Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
299
01:21Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids
258
Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2...
258
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
272
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
272
01:29Inflammatory Bowel Disease IV: Pharmacological Management
254
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
254
01:30Inflammatory Bowel Disease II: Crohn's Disease
506
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
506