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Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

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Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
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Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
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Bone Marrow Sampling and Transplants

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Structure and Function of Platelets01:18

Structure and Function of Platelets

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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Formation of the Platelet Plug01:22

Formation of the Platelet Plug

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors01:20

Antiplatelet Drugs: Prostaglandin Synthesis, P2Y12 and Glycoprotein IIb/IIIa Inhibitors

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Antiplatelet drugs emerge as frontline defenders against the insidious threat of thromboembolic diseases, where abnormal clots obstruct vital blood vessels. These drugs stand as bulwarks, inhibiting platelet aggregation and clot formation, thereby mitigating the risk of life-threatening conditions like myocardial infarction, coronary artery disease, and thrombotic strokes.
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Related Experiment Video

Updated: Nov 3, 2025

Microfluidics in Assessing Platelet Function
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Microfluidics in Assessing Platelet Function

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Platelet Transfusion-Insights from Current Practice to Future Development.

Annina Capraru1, Katarzyna Aleksandra Jalowiec1, Cesare Medri1

  • 1Department of Hematology and Central Hematology Laboratory, Inselspital, Bern University Hospital, University of Bern, 3010 Bern, Switzerland.

Journal of Clinical Medicine
|June 2, 2021
PubMed
Summary
This summary is machine-generated.

Platelet transfusion supports patients with bleeding risks. Advances in platelet concentrates, storage, and pathogen inactivation will shape future transfusion guidelines and improve patient care.

Keywords:
cold stored platelet concentratesplatelet additive solutionsplatelet pathogen inactivation/reductionplatelet transfusion alternativesplatelet transfusion guidelines

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A Microfluidic Flow Chamber Model for Platelet Transfusion and Hemostasis Measures Platelet Deposition and Fibrin Formation in Real-time
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Routine Screening Method for Microparticles in Platelet Transfusions
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Routine Screening Method for Microparticles in Platelet Transfusions

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Area of Science:

  • Hematology
  • Transfusion Medicine

Background:

  • Platelet transfusions are crucial for managing hemorrhagic complications in various medical conditions.
  • Supportive care in high-dose chemotherapy relies heavily on platelet transfusions.

Purpose of the Study:

  • To review current practices and future developments in platelet transfusion.
  • To focus on key areas impacting upcoming transfusion guidelines.

Main Methods:

  • Comparative analysis of buffy-coat (BPC) and apheresis platelet concentrates (APC).
  • Evaluation of plasma additive solutions (PAS) and methods to improve platelet storage quality.
  • Assessment of pathogen inactivation techniques and cold storage strategies for platelets.

Main Results:

  • Discussion on the efficacy and safety of different platelet concentrate types (BPC vs. APC).
  • Insights into optimizing platelet storage using additive solutions and advanced techniques.
  • Exploration of pathogen inactivation and cold storage for enhanced platelet viability.

Conclusions:

  • Emerging advances in platelet transfusion are poised to significantly alter current standards of care.
  • Key areas like concentrate type, storage solutions, pathogen inactivation, and cold storage will influence future transfusion guidelines.