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Related Experiment Video

Updated: Nov 3, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

Published on: May 9, 2025

HIV Protease: Historical Perspective and Current Research.

Irene T Weber¹, Yuan-Fang Wang¹, Robert W Harrison²

¹Department of Biology, Georgia State University, Atlanta, GA 30302, USA.

|June 2, 2021

Summary

Antiviral inhibitors target human immunodeficiency virus (HIV) protease, but drug resistance is a growing threat. Understanding HIV protease function and resistance mechanisms is crucial for developing effective HIV/AIDS treatments.

Keywords:

HIV/AIDS antiretroviral inhibitors drug resistance protease structures retroviral proteases

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Last Updated: Nov 3, 2025

Quantitative Structure-Activity Relationship, Activity Prediction, and Molecular Dynamics of Non-nucleotide Reverse Transcriptase Inhibitors

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Published on: May 9, 2025

Interview: HIV-1 Proviral DNA Excision Using an Evolved Recombinase

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Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors

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Published on: April 9, 2014

Area of Science:

Virology
Biochemistry
Drug Discovery

Background:

The human immunodeficiency virus (HIV) protease is a critical target for antiviral therapies against HIV/AIDS.
Current treatment strategies face challenges due to the emergence of drug-resistant HIV protease variants.

Observation:

This review details the historical research on HIV protease structure and function.
It examines the development of antiviral inhibitors and studies on drug resistance.

Findings:

Fundamental research on HIV protease, notably by Dr. Stephen Oroszlan, established the basis for designing clinical inhibitors.
Drug-resistant HIV protease variants offer insights into resistance evolution and molecular mechanisms.

Implications:

Continued research into HIV protease function and resistance is vital for advancing HIV/AIDS treatment and combating drug resistance.
Understanding resistance mechanisms can inform the development of next-generation antiviral therapies.