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Updated: Nov 3, 2025
12:42
Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
Published on: January 7, 2019
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Metabolic Control by DNA Tumor Virus-Encoded Proteins
Martin A Prusinkiewicz1, Joe S Mymryk1,2,3,4
1Department of Microbiology and Immunology, Western University, London, ON N6A 3K7, Canada.
Pathogens (Basel, Switzerland)
|June 2, 2021
Summary
DNA tumor viruses manipulate host cell metabolism using viral oncoproteins to regulate MYC, p53, and pRb/E2F. This interaction is key for viral replication and offers potential targets for antiviral therapies.
Area of Science:
- Virology
- Molecular Biology
- Cancer Research
Background:
- Viruses require host cell metabolic processes for replication.
- Viruses utilize viral oncoproteins to alter host metabolism.
- Key host regulators like MYC, p53, and pRb/E2F are often targeted.
Purpose of the Study:
- To review how four DNA tumor viruses influence host cell metabolism.
- To examine viral oncoprotein interactions with MYC, p53, and pRb/E2F.
- To explore therapeutic potential of targeting virus-altered metabolism.
Main Methods:
- Review of recent research on DNA tumor viruses and host metabolism.
- Analysis of viral oncoprotein interactions with specific host regulators.
- Discussion of metabolic pathways affected by viral manipulation.
Main Results:
- Human adenovirus, human papillomavirus, Epstein-Barr virus, and Kaposi's-associated-sarcoma herpesvirus alter host metabolism.
- Viral oncoproteins interact with MYC, p53, and pRb/E2F to modulate cellular processes.
- The same virus can activate or inhibit regulators depending on the oncoprotein involved.
Conclusions:
- Understanding virus-host metabolic interactions is crucial.
- Viral oncoproteins are central to metabolic reprogramming.
- Targeting these metabolic pathways may lead to novel antiviral or anticancer strategies.
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