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Essential Role of the 14q32 Encoded miRNAs in Endocrine Tumors

Lilla Krokker1, Attila Patócs1,2,3, Henriett Butz1,2,3

  • 1Department of Laboratory Medicine, Semmelweis University, H-1089 Budapest, Hungary.

Genes
|June 2, 2021
PubMed
Abstract

Insights

The 14q32 microRNA (miRNA) cluster plays a key role in endocrine gland tumors. Dysregulation of these miRNAs may offer potential as diagnostic or prognostic biomarkers for endocrine neoplasms.

Area of Science:

  • Endocrinology
  • Molecular Biology
  • Genetics

Background:

  • The 14q32 cluster is a large polycistronic microRNA (miRNA) cluster.
  • miRNAs from this cluster are involved in the tumorigenesis of various endocrine glands.

Purpose of the Study:

  • To critically review miRNA studies in endocrine tumors.
  • To investigate the relevance of 14q32 miRNAs by analyzing their targets and integrating literature and bioinformatics data.

Main Methods:

  • Comprehensive literature review of miRNA studies in endocrine tumors.
  • Bioinformatic analysis of miRNA targets.
  • Integration of existing literature data and predictive bioinformatics information.

Main Results:

  • Downregulation of 14q32 miRNAs in pituitary adenoma, papillary thyroid cancer, and subsets of pheochromocytoma and adrenocortical cancer.
  • Overexpression of 14q32 miRNAs in pancreatic neuroendocrine tumors, most adrenocortical cancers, and medullary thyroid cancer.
  • Observed both increased and decreased expression of 14q32 miRNAs in pheochromocytoma and growth-hormone producing pituitary adenoma, with hypothesized contributing factors.

Conclusions:

  • 14q32 miRNAs are significantly involved in endocrine organ tumorigenesis.
  • Stable expression of 14q32 miRNAs in circulation suggests potential as diagnostic or prognostic biomarkers for endocrine neoplasms.
Keywords:
14q32DLK1-MEG3 locusadrenocortical cancerendocrine tumormiRNAmiRNA clusterneuroendocrine tumorpheochromocytomapituitary adenomathyroid cancer

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