Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

CRISPR01:59

CRISPR

54.0K
Genome editing technologies allow scientists to modify an organism’s DNA via the addition, removal, or rearrangement of genetic material at specific genomic locations. These types of techniques could potentially be used to cure genetic disorders such as hemophilia and sickle cell anemia. One popular and widely used DNA-editing research tool that could lead to safe and effective cures for genetic disorders is the CRISPR-Cas9 system. CRISPR-Cas9 stands for Clustered Regularly Interspaced...
54.0K
CRISPR/Cas9 Genome Editing01:28

CRISPR/Cas9 Genome Editing

780
The CRISPR-Cas system serves as a bacterial defense mechanism against invading genetic elements such as viruses and plasmids, forming the foundation for its adaptation as a powerful genome-editing tool. Originally discovered in prokaryotes, this system has been repurposed to revolutionize genetic engineering across a wide range of organisms, including plants, animals, and humans. The core component, Cas9, is an endonuclease derived from Streptococcus pyogenes, capable of introducing...
780
What is Genetic Engineering?00:49

What is Genetic Engineering?

76.5K
Overview
76.5K
Natural Selection and Adaptation01:15

Natural Selection and Adaptation

891
Natural selection, a fundamental concept in evolutionary biology, is the mechanism by which evolution is driven, favoring organisms that are best adapted to their environments. This process enhances their chances of survival and reproduction. Adaptation, a key outcome of this process, involves genetic modifications that optimize an organism's functionality under specific environmental challenges, such as extreme cold or thinner air at high altitudes.
Beyond physical adaptations,...
891

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A Systems Biology Approach to Discovery and Validation of MicroRNA Signature Health Risks Associated with the Space Environment.

Methods in molecular biology (Clifton, N.J.)·2026
Same author

The <i>Non-Coding RNA</i> Journal Club: Highlights on Recent Papers-14.

Non-coding RNA·2025
Same author

Cross-Kingdom Enzymatic Strategies for Deoxynivalenol Detoxification: Computational Analysis of Structural Mechanisms and Evolutionary Adaptations.

Microorganisms·2025
Same author

Importance of De Novo Gene Evolution to Emerging Viral Threats: The ORF10 Strain-Restricted Orphan Gene of SARS-CoV-2 Promotes Pathogenesis.

Molecular biology and evolution·2025
Same author

MicroRNA-143-3p and miR-452-5p: A Fingerprint for the Diagnosis of Aortic Stenosis in the Geriatric Population.

Biomedicines·2025
Same author

The Unpaved Road of Non-Coding RNA Structure-Function Relationships: Current Knowledge, Available Methodologies, and Future Trends.

Non-coding RNA·2025

Related Experiment Video

Updated: Nov 3, 2025

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

34.7K

Non-Random Genome Editing and Natural Cellular Engineering in Cognition-Based Evolution.

William B Miller1, Francisco J Enguita2, Ana Lúcia Leitão3

  • 1Banner Heath Systems, Phoenix, AZ 85006, USA.

Cells
|June 2, 2021
PubMed
Summary

Cognition-Based Evolution proposes that biological novelty arises from cellular problem-solving and purposeful genetic adjustments, not random errors. This framework highlights intelligent cells and natural cellular engineering as drivers of evolutionary variation.

Keywords:
cognition-based evolutionholobiontnatural cellular engineeringnatural genetic engineeringniche constructionself-referencesenome

More Related Videos

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
07:13

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

Published on: November 29, 2024

1.5K
CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery
07:49

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery

Published on: May 30, 2025

1.7K

Related Experiment Videos

Last Updated: Nov 3, 2025

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms
09:51

Enhanced Genome Editing with Cas9 Ribonucleoprotein in Diverse Cells and Organisms

Published on: May 25, 2018

34.7K
Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function
07:13

Electroporation of Sliced Human Cortical Organoids for Studies of Gene Function

Published on: November 29, 2024

1.5K
CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery
07:49

CRISPR Epigenome Editing in Human Cells using Plasmid DNA Transfection and mRNA Nucleofection Delivery

Published on: May 30, 2025

1.7K

Area of Science:

  • Evolutionary biology
  • Cell biology
  • Genetics

Background:

  • Neo-Darwinism posits random genetic mutations and natural selection drive evolution.
  • Phenotypic variation and biological novelty require a more comprehensive explanation.

Purpose of the Study:

  • Introduce Cognition-Based Evolution (CBE) as an alternative to Neo-Darwinism.
  • Explain the role of intelligent cells and natural cellular engineering in generating variation.
  • Reframe the understanding of genetic mechanisms in evolution.

Main Methods:

  • Conceptual framework development based on cellular information processing.
  • Analysis of multicellularity as a collective cellular measurement strategy.
  • Integration of epigenetics, environmental stress, and genomic editing.

Main Results:

  • Evolutionary variation results from cellular problem-solving and purposive genetic adjustments.
  • Multicellularity arises from cells collectively assessing ambiguous environmental information.
  • Natural genomic editing, influenced by epigenetics and stress, enables non-random variation.

Conclusions:

  • Intelligent cells and natural cellular engineering are central to biological variation.
  • Genes function as cellular tools, harnessed for adaptation.
  • Multicellular eukaryotes, as holobionts, exhibit variation through co-engineering among diverse cellular components.