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Related Experiment Video

Updated: Nov 3, 2025

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity

Published on: April 26, 2012

Oxaliplatin Causes Transient Changes in TRPM8 Channel Activity.

Vittoria Rimola¹, Tabea Osthues², Vanessa Königs²

¹Institute of Clinical Pharmacology, Pharmazentrum Frankfurt/ZAFES, University Hospital, Goethe-University, 60590 Frankfurt am Main, Germany.

International Journal of Molecular Sciences

|June 2, 2021

Summary

Oxaliplatin treatment transiently increases the activity of the TRPM8 channel, a key player in cold sensitivity. This early change, linked to the PLC pathway, may explain acute pain following chemotherapy.

Keywords:

TRPM8 acute pain desensitization neuropathic pain oxaliplatin

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Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4

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Published on: December 31, 2013

Area of Science:

Neuroscience
Pharmacology
Oncology

Background:

Oxaliplatin is a crucial chemotherapy drug for colorectal cancer.
Patients often experience acute peripheral pain and chronic neuropathy after oxaliplatin treatment.
The mechanisms behind oxaliplatin-induced acute pain remain unclear.

Purpose of the Study:

To investigate the role of TRP channels in oxaliplatin-induced acute pain.
To elucidate the molecular mechanisms underlying these pain responses.

Main Methods:

Examined the activity of TRPM8 and other TRP channels after oxaliplatin treatment.
Investigated the involvement of the phospholipase C (PLC) pathway and PIP2 levels.
Assessed the effects of PLC inhibition on TRPM8 activity and PIP2 concentrations.

Main Results:

Oxaliplatin treatment transiently increased TRPM8 channel activity 1 hour post-treatment.
TRPM8 activity decreased 24 hours after oxaliplatin, linked to PLC activation and PIP2 depletion.
Inhibiting the PLC pathway restored TRPM8 activity and PIP2 levels.

Conclusions:

Transient changes in TRPM8 activity early after oxaliplatin treatment are identified.
Later TRPM8 channel desensitization in sensory neurons may contribute to chronic pain.
TRPM8 plays a significant role in both acute and neuropathic pain induced by oxaliplatin.