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Urea as a Cocrystal Former-Study of 3 Urea Based Pharmaceutical Cocrystals
Fucheng Leng1, Koen Robeyns1, Tom Leyssens1
1Institute of Condensed Matter and Nanosciences, Université Catholique de Louvain, B-1348 Louvain-La-Neuve, Belgium.
Abstract:
Cocrystallization is commonly used for its ability to improve the physical properties of APIs, such as solubility, bioavailability, compressibility, etc. The pharmaceutical industry is particularly interested in those cocrystals comprising a GRAS former in connection with the target API. In this work, we focus on the potential of urea as a cocrystal former, identifying three novel pharmaceutical cocrystal systems with catechin, 3-hydroxyl-2-naphthoic and ellagic acid. Interestingly, the stability of catechin under high humidity or high temperature environment is improved upon cocrystallization with urea. Moreover, the solubility of ellagic acid is improved about 17 times. This work displays the latent possibility of urea in improving the physical property of drug molecules using a cocrystallization approach.
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