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Heating reactivation of rats aminolevulinic acid dehydratase in lead poisoning
A Trevisan1, M Raimondi, A Bungaro
1Istituto di Medicina del Lavoro, Università di Padova, Italy.
The Science of the Total Environment
|June 1, 1988
Abstract:
Heat reactivation (60 degrees C for 5 minutes) of the red blood cells aminolevulinic acid dehydratase activity was studied in lead treated rats (0.25 to 5.0 mg/kg b.w., i.p., for 4 weeks). Complete enzyme reactivation occurs with lead blood concentration up to about 70 mcg/dl. At higher blood lead concentrations, only a part of the enzyme can be restored by heating. The different mechanisms of aminolevulinic acid dehydratase activity inhibition by lead are discussed.