Related Experiment Video

Updated: Nov 3, 2025

Protocol for the Differentiation of Human Induced Pluripotent Stem Cells into Mixed Cultures of Neurons and Glia for Neurotoxicity Testing
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Keap1/Nrf2 Signaling Pathway

Gerasimos P Sykiotis1,2

  • 1Service of Endocrinology, Diabetology and Metabolism, Lausanne University Hospital, 1011 Lausanne, Switzerland.

Antioxidants (Basel, Switzerland)
|June 2, 2021
PubMed
Summary

Nuclear factor erythroid 2-like 2 (Nrf2) and its inhibitor Keap1 regulate cellular defense against oxidative stress. This pathway is crucial for maintaining cellular balance and protecting against damage.

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