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Cell Diversity01:13

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The concept of a cell started with microscopic observations of dead cork tissue by Robert Hooke in 1665. Hooke coined the term "cell" based on the resemblance of the small subdivisions in the cork to the rooms that monks inhabited, called cells. About ten years later, Antonie van Leeuwenhoek became the first person to observe the living and moving cells under a microscope. In the century that followed, the theory that cells represented the basic unit of life developed.
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Nanomaterial Shape Influence on Cell Behavior.

Daniil V Kladko1, Aleksandra S Falchevskaya1, Nikita S Serov1

  • 1International Institute "Solution Chemistry of Advanced Materials and Technologies", ITMO University, 191002 Saint Petersburg, Russia.

International Journal of Molecular Sciences
|June 2, 2021
PubMed
Summary
This summary is machine-generated.

Nanomaterial shape significantly influences biological cell activities, impacting metabolism and proliferation. This review covers shape control, synthesis, and biological effects of nanomaterials.

Keywords:
anisotropiccrystal growthmammalian cellmicrobial cellnanoparticleshape

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Area of Science:

  • Biomaterials Science
  • Cellular Biology
  • Nanotechnology

Background:

  • Nanomaterials profoundly affect mammalian and microbial cells, but research often focuses only on surface chemistry, charge, and area.
  • Existing studies predominantly investigate nanomaterial cytotoxicity, overlooking broader biological impacts.
  • The critical role of nanomaterial shape in cellular processes like metabolism and proliferation is increasingly recognized.

Purpose of the Study:

  • To review mechanisms of nanomaterial shape control and synthesis approaches.
  • To explore the influence of nanomaterial shape on cellular activities including metabolism, proliferation, and differentiation.
  • To discuss the future prospects of research into nanomaterial shape-dependent biological effects.

Main Methods:

  • Literature review of studies on nanomaterial synthesis and characterization.
  • Analysis of research investigating nanomaterial interactions with mammalian and microbial cells.
  • Synthesis of findings on shape-dependent biological responses.

Main Results:

  • Nanomaterial shape is a crucial factor influencing cellular metabolism, proliferation, and differentiation.
  • Specific synthesis methods allow for controlled nanomaterial shaping.
  • Beyond cytotoxicity, nanomaterials impact a wide range of cellular functions.

Conclusions:

  • Nanomaterial shape is a key determinant of biological activity, extending beyond cytotoxicity.
  • Controlled synthesis of specific nanomaterial shapes is essential for harnessing their biological potential.
  • Further research into shape-dependent effects will advance nanomedicine and biotechnology.