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Updated: Nov 3, 2025

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
A Comprehensive Review on the Role of Non-Coding RNAs in the Pathophysiology of Bipolar Disorder
Soudeh Ghafouri-Fard1, Elham Badrlou1, Mohammad Taheri2
1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran 65167198721, Iran.
Aim:
Bipolar disorder is a multifactorial disorder being linked with dysregulation of several genes. Among the recently acknowledged factors in the pathophysiology of bipolar disorder are non-coding RNAs (ncRNAs).
Methods:
We searched PubMed and Google Scholar databases to find studies that assessed the expression profile of miRNAs, lncRNAs and circRNAs in bipolar disorder.
Results:
Dysregulated ncRNAs in bipolar patients have been enriched in several neuron-related pathways such as GABAergic and glutamatergic synapses, morphine addiction pathway and redox modulation.
Conclusion:
Altered expression of these transcripts in bipolar disorder provides clues for identification of the pathogenesis of this disorder and design of targeted therapies for the treatment of patients.
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