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Secreted Enzyme-Responsive System for Controlled Antifungal Agent Release
Andrea Bernardos1,2,3, Matěj Božik1, Ana Montero1
1Department of Food Science, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Kamýcká 129, 16500 Praha-Suchdol, Czech Republic.
Nanomaterials (Basel, Switzerland)
|June 2, 2021
Summary
This study developed biomimetic systems using mesoporous silica nanoparticles (MSN) to control eugenol release for antifungal applications. Maltodextrin- and maltose-capped MSNs effectively delivered eugenol in the presence of Aspergillus niger, inhibiting fungal growth.
Area of Science:
- Biomaterials Science
- Plant Science
- Mycology
Background:
- Essential oil components (EOCs) like eugenol are crucial for plant antimicrobial defense.
- Natural EOCs face challenges in application due to volatility and reactivity.
- Plants utilize sophisticated storage and release systems for EOCs.
Purpose of the Study:
- To create biomimetic systems for controlled eugenol release, mimicking plant defense strategies.
- To evaluate the antifungal activity of eugenol-loaded mesoporous silica nanoparticles (MSN) against Aspergillus niger.
- To investigate the effect of different saccharide capping agents on eugenol delivery.
Main Methods:
- Preparation of eugenol-loaded MSN capped with starch, maltodextrin, maltose, and glucose.
- Assessment of eugenol release profiles in the presence and absence of Aspergillus niger.
- Evaluation of the antifungal efficacy of the developed systems against Aspergillus niger.
Main Results:
- Maltodextrin- and maltose-capped MSNs exhibited minimal eugenol release without the fungus.
- These systems demonstrated significant eugenol delivery upon encountering Aspergillus niger.
- Degradation of saccharide gates by exogenous enzymes triggered eugenol release and potent fungal growth inhibition.
Conclusions:
- Biomimetic MSN systems offer a promising approach for controlled eugenol delivery.
- Saccharide-capped MSNs provide a smart release mechanism responsive to fungal presence.
- These findings highlight potential applications in developing novel antifungal agents.
Keywords:
Aspergillus nigerantifungalantimicrobialessential oil componentexogenous enzymenanoparticlesMore Related Videos
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