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Production of Genetically Engineered Golden Syrian Hamsters by Pronuclear Injection of the CRISPR/Cas9 Complex

Production of Genetically Engineered Golden Syrian Hamsters by Pronuclear Injection of the CRISPR/Cas9 Complex

Published on: January 9, 2018

Hamster Polyomavirus Research: Past, Present, and Future.

Burkhard Jandrig¹, Hans Krause², Wolfgang Zimmermann³

¹Department of Urology, University Medical Center Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Germany.

|June 2, 2021

Summary

Hamster polyomavirus (HaPyV) is a key tumor model in Syrian hamsters, crucial for understanding skin tumors and lymphomas. Its major capsid protein VP1 is versatile for creating virus-like particles for research and potential vaccines.

Keywords:

Syrian hamster genome organization major capsid protein middle T antigen rodent polyomaviruses tumor model virus discovery virus-like particles

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Published on: September 13, 2018

Area of Science:

Virology and Oncology
Rodent Tumor Models
Viral Vector Technology

Background:

Hamster polyomavirus (HaPyV) was identified in the 1960s in Syrian hamsters with skin tumors.
HaPyV infections are linked to skin tumors and lymphomas in Syrian hamsters, establishing it as a significant tumor model.
Phylogenetic analysis places HaPyV within the *Alphapolyomavirus* genus, distinct from other cricetid polyomaviruses.

Purpose of the Study:

To review the significance of HaPyV as a tumor model in Syrian hamsters.
To explore the applications of HaPyV's major capsid protein (VP1) in generating virus-like particles (VLPs).
To highlight future research directions for HaPyV, including evolutionary studies and potential therapeutic applications.

Main Methods:

Analysis of HaPyV genome structure, including early and late transcriptional regions.
Characterization of HaPyV tumor antigens and capsid proteins (VP1, VP2).
Generation and application of autologous, chimeric, and mosaic virus-like particles (VLPs) using HaPyV VP1.

Main Results:

HaPyV genome contains typical polyomavirus early (T antigens) and late (capsid proteins) regions.
HaPyV VP1 protein serves as a flexible carrier for creating VLPs with diverse applications.
VLPs derived from HaPyV VP1 are useful for antibody production, dendritic cell studies, and insertion of foreign sequences.

Conclusions:

HaPyV remains a valuable and pioneering tumor model in Syrian hamsters.
The HaPyV VP1 protein offers significant potential for developing VLP-based technologies.
Further research into HaPyV's evolution, prevalence, and therapeutic potential is warranted for vaccine and gene therapy development.