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Impact of Kidney Failure on the Severity of COVID-19

Dorota Zarębska-Michaluk1, Jerzy Jaroszewicz2, Magdalena Rogalska3

  • 1Department of Infectious Diseases, Jan Kochanowski University, 25-317 Kielce, Poland.

Journal of Clinical Medicine
|June 2, 2021
PubMed

Insights

Patients with kidney failure face a higher risk of severe coronavirus disease 2019 (COVID-19) and mortality. This study identified key risk factors for fatal outcomes in this vulnerable population.

Area of Science:

  • Nephrology
  • Infectious Diseases
  • Critical Care Medicine

Background:

  • Patients with kidney failure exhibit increased vulnerability to severe coronavirus disease 2019 (COVID-19).
  • High mortality rates are associated with COVID-19 in individuals with renal failure.

Purpose of the Study:

  • To evaluate the impact of renal failure on COVID-19 severity.
  • To identify risk factors contributing to fatal outcomes in COVID-19 patients with kidney failure.

Main Methods:

  • Analysis of a national real-world study (SARSTer database) involving 30 Polish centers.
  • Retrospective data collection and online submission from 2322 COVID-19 patients.

Main Results:

  • Kidney failure was present in 19.65% of patients (455/2322), with 82 cases of severe renal failure.
  • Patients with kidney failure were older and experienced more severe COVID-19.
  • Independent predictors of 28-day mortality included age, baseline SpO2, disease severity scale, neutrophil and platelet counts, eGFR, C-reactive protein, malignancy, and arterial hypertension.

Conclusions:

  • Underlying kidney disease is a primary factor linked to severe COVID-19 presentation.
  • Kidney disease significantly increases the mortality rate in COVID-19 patients.
Abstract

Keywords:
COVID-19SARS-CoV-2kidney failuremortality

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