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Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Defense Against Bacterial Pathogens01:31

Defense Against Bacterial Pathogens

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The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
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Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Infection01:20

Infection

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When a pathogen enters the body and reproduces, it can cause an infection, damage body cells, and cause illness symptoms that eventually lead to disease. Therefore, its prevention requires breaking the chain of infection.
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Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

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Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
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Gene Regulation in Microbial Communities: Quorum Sensing01:28

Gene Regulation in Microbial Communities: Quorum Sensing

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Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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Updated: Nov 3, 2025

Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
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Development and Assessment of Intracellular Infection Models for Staphylococcus aureus

Published on: January 17, 2025

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Staphylococcal Infections: Host and Pathogenic Factors.

Rajan P Adhikari1

  • 1Integrated Biotherapeutics Inc., Rockville, MD 20878, USA.

Microorganisms
|June 2, 2021
PubMed
Summary

Staphylococci, bacteria resembling grape clusters, were first identified in 1880 by surgeon Alexander Ogston. These microorganisms are significant in surgical site infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Surgical Pathology

Background:

  • The discovery of staphylococci by Sir Alexander Ogston in 1880 marked a significant advancement in understanding bacterial pathogens.
  • Ogston's initial observation of these bacteria in knee joint abscess pus, described as "bunches of grapes," provided crucial morphological insights.

Discussion:

  • Staphylococci are Gram-positive bacteria known for their role in a wide range of human infections, particularly those associated with healthcare settings.
  • Their characteristic morphology, resembling grape-like clusters, is a key feature used in their identification and classification.

Key Insights:

  • The historical identification of staphylococci by Ogston laid the groundwork for future research into their pathogenic mechanisms.
  • Understanding the morphology and origin of staphylococci is fundamental to developing effective antimicrobial strategies and infection control measures.

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Outlook:

  • Continued research into staphylococcal virulence factors and antibiotic resistance is essential for combating persistent infections.
  • Advances in diagnostics and therapeutics aim to improve patient outcomes in staphylococcal infections.