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Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents

Samir Mohamed Awad1, Shima Mahmoud Ali2, Yara Essam Mansour1

  • 1Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Helwan University, Ain-Helwan, Cairo 11795, Egypt.

Molecules (Basel, Switzerland)
|June 2, 2021
PubMed

Keywords:
acyclic nucleosidesantiviral activitiescyclic nucleosidesuracil

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Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
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