Related Experiment Video

Updated: Nov 3, 2025

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.5K

Prognosis of Coronary Atherosclerotic Burden in Non-Ischemic Dilated Cardiomyopathies

Marjorie Canu1, Léa Margerit1, Ismail Mekhdoul1

  • 1Department of Cardiology, University Hospital, 38000 Grenoble Alpes, France.

Journal of Clinical Medicine
|June 2, 2021
PubMed

Insights

High coronary atherosclerotic burden (CAB) is a significant predictor of major adverse cardiovascular events (MACE) in patients with non-ischemic dilated cardiomyopathy (dCMP). This finding suggests CAB may be a new prognostic factor for dCMP.

Area of Science:

  • Cardiology
  • Cardiovascular Imaging
  • Cardiovascular Disease

Background:

  • Atherosclerosis is linked to poor outcomes in ischemic cardiomyopathy.
  • The prognostic significance of coronary atherosclerotic burden (CAB) in non-ischemic dilated cardiomyopathy (dCMP) is less understood.

Purpose of the Study:

  • To investigate the prognostic impact of CAB in patients diagnosed with dCMP.

Main Methods:

  • 139 dCMP patients with left ventricular dysfunction underwent invasive coronary angiography and cardiac magnetic resonance (CMR) imaging.
  • Coronary atherosclerotic burden (CAB) was quantified using the Gensini score.
  • Major adverse cardiovascular events (MACE) were tracked over a median follow-up of 2.8 years.

Main Results:

  • Patients experiencing MACE had significantly higher CAB compared to those without events (p < 0.0001).
  • Coronary atherosclerotic burden (CAB) independently predicted MACE in multivariate analysis (OR: 1.12, p = 0.02).

Conclusions:

  • Elevated coronary atherosclerotic burden (CAB) may serve as a novel prognostic marker in patients with non-ischemic dilated cardiomyopathy (dCMP).
Abstract

Keywords:
cardiac magnetic resonance imagingcoronary atherosclerotic burdendilated cardiomyopathy

More Related Videos

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice06:39

Ultrasound Based Assessment of Coronary Artery Flow and Coronary Flow Reserve Using the Pressure Overload Model in Mice

Published on: April 13, 2015

15.2K
Author Spotlight: Enhancing Coronary Artery Revascularization05:25

Author Spotlight: Enhancing Coronary Artery Revascularization

Published on: September 15, 2023

953

Related Concept Videos

Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
93
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
111
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
110
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send...
1.8K
Cardiomyopathy I: Introduction and Classification01:25

Cardiomyopathy I: Introduction and Classification

Cardiomyopathy, or CMP, is a group of diseases affecting the myocardial structure, impairing its ability to pump blood effectively. This condition can lead to arrhythmias, heart failure, or sudden cardiac death.Cardiomyopathies are classified into primary and secondary categories:Primary Cardiomyopathy refers to conditions involving only the heart muscle that are often idiopathic (of unknown cause) or genetic. They primarily affect the myocardium without the involvement of other systemic...
170
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
565