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Related Concept Videos

Types of Step-Growth Polymers: Polyesters01:20

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The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
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The polymerization process that involves carbanion as an intermediate is called anionic polymerization. It is also a type of addition or chain-growth polymerization. Anionic polymerization gets initiated by a strong nucleophile such as an organolithium or a Grignard reagent. The most commonly used initiator for anionic polymerization is butyl lithium. Monomers involved in anionic polymerization must possess a vinyl group bonded to one or two electron-withdrawing groups. For instance,...
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Responsive Polyesters with Alkene and Carboxylic Acid Side-Groups for Tissue Engineering Applications.

Stella Afroditi Mountaki1,2, Maria Kaliva1,3, Konstantinos Loukelis1,3

  • 1Institute of Electronic Structure and Laser, Foundation for Research and Technology-Hellas, Vassilika Vouton, 700 13 Heraklion, Greece.

Polymers
|June 2, 2021
PubMed
Summary

Novel pH-responsive polyesters were synthesized for biomedical applications. These functional polymers exhibit tunable properties and enhanced biocompatibility, promoting cell growth for improved biomaterial performance.

Keywords:
aliphatic polyestersbiocompatibilitybiodegradable polymerspH-sensitive polymersresponsive materialssmart polymerstissue engineering

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Area of Science:

  • Polymer Chemistry
  • Biomaterials Science
  • Organic Synthesis

Background:

  • Main chain polyesters are widely used in biomedicine due to biocompatibility and biodegradability.
  • Existing polyesters often lack specific functionalities, limiting their biological and responsive properties.
  • There is a need for advanced polyesters with tailored characteristics for enhanced biomedical applications.

Purpose of the Study:

  • To develop novel pH-responsive main chain polyesters.
  • To functionalize polyesters with carboxylic acid side-groups via click chemistry.
  • To investigate the influence of side-group modification on polymer properties and biocompatibility.

Main Methods:

  • Condensation polymerization of vinyl functionalized diol with diacid chloride.
  • Photo-induced thiol-ene click reaction to attach mercaptocarboxylic acids.
  • Tuning polymer properties by varying alkyl chain length and carboxylic acid content.

Main Results:

  • Successfully synthesized pH-responsive polyesters with adjustable pKa values and water solubilities.
  • Demonstrated control over polymer modification degree and side-group characteristics.
  • Developed cross-linked polyester films with enhanced biocompatibility, promoting cell viability, proliferation, and attachment.

Conclusions:

  • Novel pH-responsive polyesters with tunable properties were successfully prepared.
  • Functionalization via thiol-ene click reaction offers a versatile route to modify polyester characteristics.
  • Cross-linked polyester films exhibit excellent biocompatibility, particularly with shorter alkyl chains and higher carboxylic acid content, showing promise for biomedical applications.