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Updated: Nov 3, 2025

Repression of Multiple Myeloma Cell Growth In Vivo by Single-wall Carbon Nanotube SWCNT-delivered MALAT1 Antisense Oligos
Published on: December 13, 2018
Current and Novel Alkylators in Multiple Myeloma.
Fredrik Schjesvold1,2, Albert Oriol3
1Oslo Myeloma Center, Oslo University Hospital, 0450 Oslo, Norway.
Alkylating drugs remain crucial in myeloma treatment despite new therapies. Research reviews traditional agents like cyclophosphamide and melphalan, alongside novel alkylators, highlighting their continued importance.
Area of Science:
- Oncology
- Pharmacology
Background:
- Novel myeloma treatments have emerged, yet alkylating drugs persist in standard care.
- New alkylating agents are under development, indicating ongoing relevance.
Purpose of the Study:
- To review the history, current applications, and future concepts of traditional alkylating drugs in myeloma.
- To present data on the novel pro-drug melflufen.
Main Methods:
- Non-systematized literature search for relevant papers and conference communications.
- Incorporation of authors' expert knowledge in the field.
Main Results:
- Traditional alkylators (cyclophosphamide, bendamustine, melphalan) remain integral to myeloma treatment regimens.
- New alkylating drugs are entering the market, signifying continued innovation.
Conclusions:
- Alkylating drugs are essential in myeloma therapy, even with advancements in targeted and personalized medicine.
- The development of novel alkylators underscores their enduring role in managing myeloma.
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