Graphene Oxide Topical Administration: Skin Permeability Studies.

Area of Science:

• Materials Science
• Nanotechnology
• Dermatology

Background:

• Nanostructured carriers enhance dermatological drug delivery.
• Graphene oxide (GO) possesses properties suitable for pharmaceutical applications.

Purpose of the Study:

• To evaluate graphene oxide nanoparticles (GOn) for topical administration and photothermal therapy.
• To assess GOn skin permeation, stability, and biocompatibility.

Main Methods:

• Characterization of GOn size, charge, and stability.
• In vitro skin permeation studies.
• Photothermal effect assessment and cytotoxicity testing on human skin fibroblasts.

Main Results:

• GOn (197.6 nm) demonstrated stability in water for over 6 months.
• 55.5% GOn mass permeated skin within 6 hours; no permeation for larger graphite particles.
• GOn exhibited mild photothermal heating (up to 45.7 °C) and showed no toxicity to skin cells.

Conclusions:

• Graphene oxide nanoparticles are effective for topical delivery and photothermal therapy.
• GOn offers a safe and stable nanocarrier for dermatological applications.