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SERS-Based Aptasensor for Rapid Quantitative Detection of SARS-CoV-2.

Elena Zavyalova1, Oganes Ambartsumyan2, Gleb Zhdanov1

  • 1Chemistry Department, Lomonosov Moscow State University, 119991 Moscow, Russia.

Nanomaterials (Basel, Switzerland)
|June 2, 2021
PubMed
Summary

A new surface-enhanced Raman scattering (SERS) aptasensor offers rapid and specific detection of SARS-CoV-2. This colloidal solution-based method enables quantitative virus determination, distinguishing it from other respiratory viruses.

Keywords:
COVID-19SARS-CoV-2SERSaptameroptical sensorrespiratory viral infectionssilver colloids

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Area of Science:

  • Biotechnology
  • Nanotechnology
  • Analytical Chemistry

Background:

  • The COVID-19 pandemic highlighted the need for sensitive and rapid viral detection methods.
  • Surface-enhanced Raman scattering (SERS) offers high sensitivity for new detection techniques.
  • Existing SERS aptasensors for rapid virus detection often lack quantitative capability or are complex and costly.

Purpose of the Study:

  • To develop a rapid, specific, and quantitative SERS-aptasensor for SARS-CoV-2 detection.
  • To overcome limitations of existing SERS-based aptasensors regarding quantification and complexity.
  • To create a SERS-aptasensor based on colloidal solutions for improved usability.

Main Methods:

  • Modification of SERS materials with DNA aptamers for specificity.
  • Utilizing colloidal solutions for SERS-aptasensor construction.
  • Developing a method for quantitative determination of SARS-CoV-2.

Main Results:

  • The developed SERS-aptasensor demonstrates high sensitivity and specificity for SARS-CoV-2.
  • The method allows for rapid and quantitative determination of the virus.
  • The aptasensor successfully discriminates SARS-CoV-2 from other respiratory viruses.

Conclusions:

  • A novel SERS-aptasensor based on colloidal solutions has been successfully developed.
  • This technology provides a rapid, specific, and quantitative method for SARS-CoV-2 detection.
  • The aptasensor offers a promising solution for distinguishing SARS-CoV-2 from other respiratory pathogens.