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Tracking Mouse Bone Marrow Monocytes In Vivo
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Radiotracers for Bone Marrow Infection Imaging.

Lars Jødal1, Pia Afzelius2, Aage Kristian Olsen Alstrup3,4

  • 1Department of Nuclear Medicine, Aalborg University Hospital, DK-9000 Aalborg, Denmark.

Molecules (Basel, Switzerland)
|June 2, 2021
PubMed
Summary
This summary is machine-generated.

Diagnosing bone marrow infections like osteomyelitis is challenging. This review explores radiotracers, including established and developing options, to improve imaging accuracy for these infections.

Keywords:
FDGFDSGa-citrateIL-8PETSPECTSiglec-9UBImethionineosteomyelitisradionuclidesubiquicidin

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Area of Science:

  • Nuclear Medicine
  • Radiochemistry
  • Infectious Diseases

Background:

  • Medical imaging relies on radiotracers for techniques like scintigraphy, SPECT, and PET.
  • Diagnosing bone marrow infections (osteomyelitis) lacks a single, highly accurate routine test.
  • Radiotracers offer potential for improved diagnostic accuracy in osteomyelitis.

Purpose of the Study:

  • To review radiotracers used for imaging bone marrow infections.
  • To explain the physiological uptake mechanisms of these radiotracers.
  • To discuss established and developing radiotracers for osteomyelitis detection.

Main Methods:

  • Literature review of radiotracers for bone marrow infection imaging.
  • Focus on physiological uptake mechanisms relevant to infection detection.
  • Categorization of tracers into established and under-development groups.

Main Results:

  • Established radiotracers include [67Ga]Ga-citrate, radiolabeled leukocytes, nanocolloids, phosphonates, and [18F]FDG.
  • Developing tracers encompass [68Ga]Ga-citrate, [18F]FDS, [15O]water, [11C]methionine, [11C]donepezil, [99mTc]Tc-IL-8, [68Ga]Ga-Siglec-9, phage peptides, and antimicrobial peptides.

Conclusions:

  • No single radiotracer is ideal for all bone marrow infection imaging.
  • Each radiotracer provides unique physiological or biochemical information.
  • Understanding uptake mechanisms, pitfalls, and challenges is crucial for radiotracer development and application.