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Related Concept Videos

Cancer Cell Migration through Invadopodia01:35

Cancer Cell Migration through Invadopodia

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Invadosome is a broad category of cell surface structures with proteolytic activity that  degrades the extracellular matrix (ECM). Invadosomes are present in normal cell types, including macrophages, endothelial cells, and neurons, as well as tumor cells. Although the macrophage podosomes and tumor cell invadopodia are classified as invadosomes, they have different structures, molecular pathways, and functions. Podosomes are short structures that last for a few minutes. However,...
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Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
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Related Experiment Video

Updated: Nov 3, 2025

Mouse Bladder Wall Injection
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Fascin Inhibitors Decrease Cell Migration and Adhesion While Increase Overall Survival of Mice Bearing Bladder

Zhankui Zhao1, Yufeng Wang1, J Jillian Zhang2

  • 1Department of Physiology and Biophysics, Weill Cornell Medical College of Cornell University, New York, NY 10065, USA.

Cancers
|June 2, 2021
PubMed
Summary

A novel fascin inhibitor shows promise for treating metastatic bladder cancer by reducing tumor growth and improving survival in mice. This compound may offer a new therapeutic option for patients with advanced bladder cancer.

Keywords:
anti-PD-1bladder cancercisplatincytoskeletonfascintumor metastasis

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Area of Science:

  • Oncology
  • Cancer Biology
  • Pharmacology

Background:

  • Bladder cancer is a prevalent malignancy with high recurrence rates after surgery.
  • Metastatic bladder cancer has a poor prognosis, highlighting the need for novel therapeutic strategies.
  • Fascin is an actin-bundling protein implicated in cancer cell migration and invasion.

Purpose of the Study:

  • To investigate the therapeutic potential of a novel fascin inhibitor in bladder cancer.
  • To evaluate the efficacy of the fascin inhibitor in preclinical models of bladder cancer.

Main Methods:

  • In vitro assessment of bladder cancer cell migration and adhesion.
  • In vivo studies using mouse models of bladder cancer to evaluate tumor growth and survival.
  • Combination therapy studies with cisplatin and anti-PD-1 antibody.

Main Results:

  • The fascin inhibitor significantly reduced bladder cancer cell migration and adhesion in vitro.
  • In vivo, the inhibitor decreased primary tumor growth and prolonged overall survival in mice.
  • Combination therapy with cisplatin or anti-PD-1 antibody demonstrated enhanced efficacy.

Conclusions:

  • Fascin inhibitors represent a promising new class of drugs for bladder cancer treatment.
  • This novel fascin inhibitor warrants further clinical investigation for metastatic bladder cancer.
  • Combination strategies may enhance the effectiveness of fascin inhibitors in bladder cancer therapy.