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Association between Geriatric Nutritional Risk Index and Post-Stroke Cognitive Outcomes
Minwoo Lee1, Jae-Sung Lim1,2, Yerim Kim3
1Department of Neurology, Hallym University Sacred Heart Hospital, Hallym University College of Medicine, Anyang 14068, Korea.
Nutrients
|June 2, 2021
Summary
Low geriatric nutritional risk index (GNRI) scores were linked to increased risk of post-stroke cognitive impairment (PSCI) 3 months after ischemic stroke. This highlights the importance of nutritional status in stroke recovery and cognitive function.
Area of Science:
- Neurology
- Nutritional Science
- Geriatrics
Background:
- The relationship between nutritional status and post-stroke cognitive impairment (PSCI) remains unclear.
- The Geriatric Nutritional Risk Index (GNRI) is a potential indicator of nutritional status in older adults.
Purpose of the Study:
- To investigate the association between the GNRI and domain-specific cognitive outcomes 3 months after ischemic stroke.
- To determine if nutritional status, assessed by GNRI, predicts PSCI.
Main Methods:
- 344 patients with acute ischemic stroke were analyzed.
- GNRI was calculated using serum albumin and body weight, dichotomized into low (<98) and normal risk groups.
- PSCI was defined by cognitive domain z-scores below -2 SD; logistic and linear regression analyses were performed.
Main Results:
- 70 patients (20.3%) developed PSCI at 3 months.
- A low GNRI (n=59, 17.2%) was independently associated with PSCI (OR, 2.04; 95% CI, 1.00-4.14) after adjusting for confounders.
- GNRI scores correlated with Mini-Mental Status Examination and frontal domain cognitive z-scores (p<0.05).
Conclusions:
- Low GNRI is an independent predictor of PSCI development 3 months post-ischemic stroke.
- GNRI scores are specifically associated with global cognition and frontal cognitive domain outcomes.
