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Updated: Aug 31, 2026

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology
08:01

Detection of Invasive Pulmonary Aspergillosis in Haematological Malignancy Patients by using Lateral-flow Technology

Published on: March 22, 2012

Invasive pulmonary aspergillosis of horses: an association with acute enteritis

R F Slocombe1, D O Slauson

  • 1Department of Pathology, College of Veterinary Medicine, Michigan State University, East Lansing.

Veterinary Pathology
|July 1, 1988
PubMed

Insights

Invasive pulmonary aspergillosis in horses is often linked to intestinal issues and Salmonella, rather than spore inhalation. Immunocompromise and gut damage are key factors in this equine disease.

Area of Science:

  • Veterinary Medicine
  • Mycology
  • Equine Pathology

Background:

  • Invasive pulmonary aspergillosis is a serious fungal infection in horses.
  • Previous understanding suggested spore inhalation as the primary route of infection.

Purpose of the Study:

  • To investigate the causes and predisposing factors of invasive pulmonary aspergillosis in horses.
  • To determine the primary route of Aspergillus spp. invasion in equine pulmonary infections.

Main Methods:

  • Retrospective case study of 19 horses diagnosed with invasive pulmonary aspergillosis.
  • Analysis of clinical records, necropsy findings, and histopathological examination.
  • Correlation of pulmonary lesions with enterocolitis, Salmonella infection, and predisposing conditions.

Main Results:

  • Invasive pulmonary aspergillosis was identified in 19 horses, frequently associated with enterocolitis (16 cases) and Salmonella infection (14 cases).
  • Pulmonary lesions included necrosis, vasculitis, and thrombosis surrounding fungal mycelia.
  • Predisposing factors included corticosteroid therapy, neoplasms, hepatitis, pleuritis, and peritonitis, indicating immunocompromise.

Conclusions:

  • Invasion of Aspergillus species from a damaged intestine is a more significant cause of equine pulmonary aspergillosis than spore inhalation.
  • Immunocompromise plays a critical role in the development of this condition in horses.
  • Enterocolitis and Salmonella infection are strongly associated with invasive pulmonary aspergillosis in equine cases.

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