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Psoriatic plaques in Macaca fascicularis.

M J Jayo1, M D Zanolli, J M Jayo

  • 1Department of Comparative Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, NC.

Veterinary Pathology
|July 1, 1988
PubMed
Summary

A cynomolgus monkey presented with skin lesions resembling psoriasis vulgaris. Histological examination revealed characteristic epidermal changes, including parakeratosis and microabscesses, supporting this diagnosis.

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Area of Science:

  • Dermatology
  • Primate Pathology
  • Comparative Pathology

Background:

  • Psoriasis vulgaris is a chronic inflammatory skin disease.
  • Animal models are crucial for understanding human diseases.
  • Cynomolgus monkeys are widely used in biomedical research.

Observation:

  • An adult male cynomolgus monkey exhibited erythematous plaques with white scales.
  • Skin lesions were observed on the animal's body.

Findings:

  • Microscopic examination revealed regular acanthosis and marked parakeratosis.
  • Focal absence of the stratum granulosum was noted.
  • Spongiform pustules and Munro-like microabscesses were present in the epidermis.

Implications:

  • These histological findings strongly suggest psoriasis vulgaris in the monkey.
  • This case highlights the potential for non-human primates to develop psoriasis-like conditions.
  • Further research may explore the utility of this primate model for psoriasis studies.

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