Related Experiment Video
Updated: Jul 18, 2026
13:27
Osteopathic Manipulative Treatment as a Useful Adjunctive Tool for Pneumonia
Published on: May 6, 2014
48.5K
Adjuvant Inhaled Corticosteroids in Community-Acquired Pneumonia: A Review Article
1Division of Pulmonary and Sleep Medicine, Mayo Clinic Florida, Jacksonville, FL 32224, USA.
Medical Sciences (Basel, Switzerland)
|June 2, 2021
Summary
Inhaled corticosteroids may benefit certain patients with community-acquired pneumonia (CAP) by reducing lung inflammation and avoiding systemic side effects. Further research is needed to identify specific patient groups who would benefit most from this treatment.
Area of Science:
- Pulmonology
- Pharmacology
Background:
- Community-acquired pneumonia (CAP) remains a significant global health concern, contributing to substantial morbidity and mortality.
- Inflammation plays a key role in the lung injury associated with CAP, suggesting a therapeutic role for anti-inflammatory agents.
Purpose of the Study:
- To review the efficacy of inhaled corticosteroids (ICS) as a treatment for CAP.
- To evaluate the potential for ICS to provide anti-inflammatory benefits in the lungs while minimizing systemic side effects.
Main Methods:
- A concise review of existing literature on the use of corticosteroids in CAP treatment.
- Focus on studies utilizing the inhalational route of corticosteroid administration.
Main Results:
- The role of systemic corticosteroids in CAP treatment is controversial.
- Inhaled corticosteroids offer a potential alternative to systemic administration, targeting lung inflammation directly.
- Evidence suggests potential benefits in specific patient subsets, warranting further investigation.
Conclusions:
- Inhaled corticosteroids may be a beneficial adjunct therapy for select patients with CAP.
- Further randomized controlled trials are essential to define the specific patient populations and optimal use of ICS in CAP management.
Related Concept Videos
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
01:26COPD: Management Using Bronchodilators and Corticosteroids
Chronic obstructive pulmonary isease (COPD) involves a group of progressive lung disorders characterized by persistent airflow limitation and chronic respiratory symptoms. Asthma-COPD Overlap Syndrome (ACOS), encompassing features of both asthma and Chronic obstructive pulmonary disease (COPD), is a group of progressive lung disorders that includes chronic bronchitis, emphysema, and refractory (non-reversible) asthma. ACOS leads to complex clinical presentations that combine the inflammatory...
01:20Chronic Obstructive Pulmonary Disease-I: Introduction
Chronic Obstructive Pulmonary Disease (COPD) is a long-lasting respiratory condition requiring continuous attention and care. It is a progressive lung disease that leads to breathing challenges due to airflow obstruction. It manifests as persistent respiratory symptoms and restricted airflow resulting from abnormalities in the airways and alveoli, usually due to long-term exposure to harmful particles or gases. COPD mainly consists of two primary conditions: emphysema and chronic bronchitis.
01:29Chronic Obstructive Pulmonary Disease-V: Management
Managing Chronic Obstructive Pulmonary Disease (COPD) involves a multifaceted approach to reduce symptoms, prevent exacerbations, improve overall health status, and slow disease progression. Key strategies include lifestyle modifications, pharmacotherapy, supportive therapies, and, in some cases, surgery. Here is an overview of the primary COPD management strategies:
Smoking Cessation
Smoking Cessation
01:30Asthma-IV: Diagnostic and Management
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes: