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Colonic Volume Changes in Paediatric Constipation Compared to Normal Values Measured Using MRI.

Hayfa Sharif1,2, Caroline L Hoad3, Nichola Abrehart1

  • 1Translational Medical Sciences, NIHR Nottingham Biomedical Research Centre at Nottingham University Hospitals NHS Trust, University of Nottingham, Nottingham NG7 2UH, UK.

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Summary
This summary is machine-generated.

Children with functional constipation (FC) have larger colonic volumes than healthy children. This objective measurement of colon size in FC may improve diagnosis and treatment strategies.

Keywords:
MRIchildrencolonconstipationtransitvolume

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Area of Science:

  • Pediatric Gastroenterology
  • Medical Imaging
  • Digestive Health

Background:

  • Functional constipation (FC) is a common pediatric condition.
  • Current management relies on subjective symptom reports.
  • Objective data on pediatric colonic volume is scarce, especially in physiological states.

Purpose of the Study:

  • To measure undisturbed colonic volumes in children with functional constipation (FC) using magnetic resonance imaging (MRI).
  • To establish initial normal range values for colonic volume in healthy children.
  • To investigate the correlation between colonic volume and whole gut transit time (WGTT).

Main Methods:

  • MRI was used to measure total and regional colon volumes in 35 children (16 with FC, 19 healthy controls) aged 7-18 years.
  • Colonic volumes were corrected for body surface area.
  • Linear regression analyzed the relationship between total colon volume and WGTT.

Main Results:

  • Children with FC exhibited significantly higher total colonic volumes (median 309 mL) compared to healthy controls (median 227 mL).
  • The most substantial volume increase in FC patients was observed in the sigmoid colon-rectum region.
  • A significant positive correlation was found between total colonic volume and WGTT (R = 0.56, p = 0.0005).

Conclusions:

  • This study demonstrates increased physiological colonic volumes in children with functional constipation.
  • Objective colonic volume measurement offers valuable insights into FC pathophysiology.
  • Findings may aid in refining diagnostic approaches and treatment strategies for pediatric FC.