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Updated: Nov 3, 2025

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
Published on: February 9, 2021
Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives
Han Luo1, Yong-Feng Lv2, Hong Zhang1
1College of Pharmacy, Anhui University of Chinese Medicine, Hefei 230011, China.
Abstract:
A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated mollugin with aryl azides. All the compounds were evaluated for their cytotoxicity on five human cancer cell lines (HL-60, A549, SMMC-7721, SW480, and MCF-7) using MTS assays. Among the synthesized series, most of them showed cytotoxicity and most of all, compounds 14 and 17 exhibited significant cytotoxicity of all five cancer cell lines.
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