Related Experiment Video

Updated: Nov 3, 2025

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
07:32

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

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Negative Regulation of FGFR (Fibroblast Growth Factor Receptor) Signaling

Patrycja Szybowska1,2, Michal Kostas1,2, Jørgen Wesche1,2

  • 1Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Montebello, 0379 Oslo, Norway.

Cells
|June 2, 2021
PubMed

Insights

Fibroblast growth factor receptor (FGFR) signaling is vital for human development and health. Cells employ multiple mechanisms to tightly control FGFR signaling, preventing diseases linked to its dysregulation.

Area of Science:

  • Cellular Biology
  • Molecular Signaling
  • Developmental Biology

Background:

  • Fibroblast growth factor receptor (FGFR) signaling is crucial for embryonic, fetal, and adult human development.
  • Aberrant FGFR signaling is implicated in various diseases, including skeletal disorders and cancer.
  • Strict control over the magnitude, duration, and location of FGFR signaling is essential for appropriate biological responses.

Purpose of the Study:

  • To review the cellular mechanisms that regulate and terminate FGFR signaling after receptor activation.
  • To provide an overview of the complex network of cellular processes involved in FGFR signaling control.

Main Methods:

  • Literature review of cellular mechanisms regulating FGFR signaling.
  • Analysis of endocytosis, endocytic sorting, phosphatase activity, negative regulatory proteins, and feedback phosphorylation.
  • Synthesis of information on how these mechanisms interact to control FGFR signaling.

Main Results:

  • Multiple cellular mechanisms exist to regulate and inhibit FGFR signaling.
  • These mechanisms include endocytosis, phosphatase activity, negative regulatory proteins, and feedback phosphorylation.
  • These regulatory processes can act simultaneously or sequentially to control FGFR signaling.

Conclusions:

  • Cells possess an extensive repertoire of mechanisms to tightly control FGFR signaling.
  • These integrated mechanisms prevent excessive FGFR signaling and maintain cellular homeostasis.
  • Further research is needed to fully elucidate the intricacies of FGFR signaling regulation.
Keywords:
FGFRendocytosisnegative regulationphosphatasessignaling

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