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Related Concept Videos

Appendicitis-I: Introduction01:22

Appendicitis-I: Introduction

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The appendix, a small, narrow, blind tube extending from the inferior part of the cecum, is widely regarded as a vestigial organ, having lost much of its original function through evolution. Despite its diminished role, the appendix can become inflamed, a condition known as appendicitis.
Etiology: Appendicitis can arise from various causes, primarily rooted in the obstruction of the appendix lumen. Factors contributing to this obstruction include fecal accumulation, lymphoid hyperplasia and, in...
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Appendicitis-II: Diagnostic Studies and Management01:29

Appendicitis-II: Diagnostic Studies and Management

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Diagnosing and managing appendicitis requires a structured and comprehensive approach that spans from initial assessment to postoperative care. Here is an overview of the process:
Diagnosing Appendicitis
It requires a multifaceted approach, starting with a detailed physical examination to pinpoint the location and nature of the pain and identify any associated symptoms. Laboratory tests play a crucial role. A complete Blood Count (CBC) typically reveals leukocytosis (an increased number of...
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Genome-wide Association Studies-GWAS01:11

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Updated: Nov 3, 2025

Murine Appendectomy Model of Chronic Colitis Associated Colorectal Cancer by Precise Localization of Caecal Patch
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Association between Appendicitis and Incident Systemic Sclerosis.

Kuang-Tsu Yang1, James Cheng-Chung Wei2,3,4, Renin Chang5,6

  • 1Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung 813414, Taiwan.

Journal of Clinical Medicine
|June 2, 2021
PubMed
Summary
This summary is machine-generated.

A history of appendicitis significantly increases the risk of developing systemic sclerosis (SSc). This association remained strong even after accounting for other health conditions and appendicitis definitions.

Keywords:
appendicitiscase–control studynationwidepopulation-basedsystemic sclerosis

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Area of Science:

  • Rheumatology and Immunology
  • Gastroenterology
  • Epidemiology

Background:

  • Systemic sclerosis (SSc) is a complex autoimmune disease with multifactorial etiology.
  • Previous infections and comorbidities have been explored as potential risk factors for SSc.
  • The specific role of appendicitis history in the development of SSc requires further investigation.

Purpose of the Study:

  • To investigate the association between a history of appendicitis and the risk of developing incident systemic sclerosis (SSc).
  • To identify other significant risk factors for SSc, including comorbidities and infections.

Main Methods:

  • A nationwide population-based retrospective cohort study using claims data from Taiwan (2003-2012).
  • 1595 newly diagnosed SSc cases were matched with 15,950 non-SSc controls.
  • Conditional logistic regression analysis was used to assess the association between appendicitis and SSc risk, adjusting for confounders like Charlson Comorbidity Index (CCI), periodontal disease, and infections.

Main Results:

  • A history of appendicitis was significantly associated with an increased risk of SSc (OR, 2.03; 95% CI, 1.14-3.60).
  • Higher CCI (CCI ≥ 1, OR, 8.48; 95% CI, 7.50-9.58) and periodontal disease (OR, 1.55; 95% CI, 1.39-1.74) were also significantly associated with SSc risk.
  • Sensitivity analyses confirmed the robustness of the appendicitis-SSc association across different appendicitis definitions.

Conclusions:

  • Appendicitis is a significant risk factor associated with the development of systemic sclerosis.
  • Charlson Comorbidity Index and periodontal disease are also important contributors to SSc risk.
  • Further research into the immunological mechanisms linking appendicitis to SSc is warranted.