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Proteinuria and Psoriasis Risk: A Nationwide Population-Based Study
Eun Hui Bae1, Bongseong Kim2, Su Hyun Song1
1Department of Internal Medicine, Chonnam National University Medical School & Hospital, Gwangju 61469, Korea.
Persistent proteinuria, the continuous presence of protein in urine, significantly increases the risk of developing psoriasis. The amount of protein in urine also impacts psoriasis development, highlighting a link between kidney health and skin disease.
Area of Science:
- Nephrology
- Dermatology
- Epidemiology
Background:
- Psoriasis is a chronic inflammatory skin condition linked to kidney disease.
- The relationship between proteinuria changes and psoriasis development remains unclear.
Purpose of the Study:
- To investigate the association between proteinuria status and the risk of developing psoriasis.
- To evaluate how changes and amount of proteinuria influence psoriasis incidence.
Main Methods:
- Utilized the Korean National Health Screening database for 6,576,851 individuals.
- Assessed psoriasis development (ICD-10 code L40) over a median 7.23-year follow-up.
- Analyzed psoriasis risk based on proteinuria changes (never, new, past, persistent) and amount.
Main Results:
- 162,468 (2.47%) individuals developed psoriasis.
- Persistent proteinuria significantly elevated psoriasis risk (HR 1.32).
- Higher urine protein levels correlated with increased psoriasis risk, especially with reduced eGFR.
Conclusions:
- Persistent proteinuria is a significant risk factor for psoriasis development.
- The amount of proteinuria plays a crucial role in psoriasis incidence.
- Findings emphasize the connection between kidney function markers and dermatological conditions.
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