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Updated: Nov 3, 2025
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Isolation and Flow Cytometric Analysis of Glioma-infiltrating Peripheral Blood Mononuclear Cells
Published on: November 28, 2015
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Primary Gastrointestinal T/NK Cell Lymphoma.
Eun Kyung Kim1, Mi Jang1, Woo Ick Yang2
1Department of Pathology, National Health Insurance Service Ilsan Hospital, Goyang 10444, Korea.
Cancers
|June 2, 2021
Summary
Primary gastrointestinal T/NK cell lymphomas (GI-TNKL) are rare but aggressive malignancies. This study details their subtypes, characteristics, and poor outcomes, aiding diagnosis and treatment.
Area of Science:
- Hematology
- Oncology
- Gastroenterology
Background:
- Primary gastrointestinal T/NK cell lymphoma (GI-TNKL) is a rare and diverse group of lymphoid cancers.
- Understanding its subtypes and clinical behavior is crucial for patient management.
Purpose of the Study:
- To analyze the subtype distribution, clinicopathologic features, and clinical outcomes of GI-TNKL.
- To provide insights for improved diagnosis and treatment strategies.
Main Methods:
- Retrospective analysis of 38 GI-TNKL cases.
- Evaluation of clinical and pathological characteristics.
- Assessment of patient outcomes, including progression-free and overall survival.
Main Results:
- GI-TNKL predominantly affects adults in their sixth decade with a slight male predominance.
- The most common subtypes include extranodal NK/T-cell lymphoma, nasal type (ENKTL), monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL), and intestinal T-cell lymphoma, NOS (ITCL, NOS).
- The small intestine is the most frequent site, with aggressive behavior and poor survival rates observed.
Conclusions:
- GI-TNKL is a heterogeneous group of aggressive lymphomas with distinct subtypes.
- Accurate clinicopathological analysis is essential for understanding and managing these challenging malignancies.
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