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Effect of altered gastric emptying on caffeine absorption
1Medizinische Abteilung Krankenanstalt Mutterhaus der Borromäerinen Trier.
Zeitschrift Fur Gastroenterologie
|May 1, 1988
Summary
Altered gastric emptying significantly slows caffeine absorption, particularly in gastric stasis. Gastric surgery (Billroth II) with normal emptying did not affect caffeine absorption rates.
Area of Science:
- Pharmacokinetics
- Gastroenterology
Background:
- Gastric emptying significantly influences drug absorption.
- Understanding caffeine absorption in various gastric conditions is crucial for pharmacokinetics.
Purpose of the Study:
- To investigate the impact of altered gastric emptying on caffeine absorption.
- To compare caffeine absorption in patients with gastric stasis, post-Billroth II gastrectomy, and healthy individuals with altered gastric emptying.
Main Methods:
- Caffeine absorption (tablets, 366.1 mg) was assessed in patients with gastric stasis and post-Billroth II gastrectomy.
- Healthy subjects consumed fiber-free and fiber-rich liquid test meals to slow gastric emptying.
- Pharmacokinetic parameters including absorption rate constant (KA), peak time (tmax), peak concentration (cmax), and AUC x KE were measured.
Main Results:
- Gastric stasis significantly reduced caffeine absorption rate (KA) and prolonged peak time (tmax).
- Liquid test meals (fiber-free and fiber-rich) also slowed caffeine absorption, indicated by lower KA and higher tmax compared to controls.
- Caffeine absorption rate was normal after Billroth II gastrectomy with adequate gastric emptying.
- Significantly lower peak concentrations (cmax) and AUC x KE in gastric stasis and post-gastrectomy suggest reduced bioavailability.
Conclusions:
- Altered gastric emptying, as seen in gastric stasis, significantly impairs caffeine absorption and may reduce bioavailability.
- While liquid meals can slow absorption, adequate gastric emptying post-Billroth II surgery appears to maintain normal caffeine absorption rates.