Epigenomic and Metabolomic Integration Reveals Dynamic Metabolic Regulation in Bladder Cancer.

Area of Science:

• Oncology
• Molecular Biology
• Biochemistry

Background:

• Bladder cancer (BC) poses significant clinical and economic challenges.
• Current diagnostic methods and treatments for BC are limited.
• Liquid biopsy and omics technologies offer new avenues for BC research.

Purpose of the Study:

• To review the interplay between epigenetics, metabolism, and cell signaling in BC.
• To identify how these interactions drive tumor development and progression.
• To summarize non-invasive biomarkers for clinical application in BC.

Main Methods:

• Literature review focusing on epigenetics, metabolism, and cell signaling in BC.
• Analysis of the role of chromatin remodelers and metabolic pathways.
• Identification of key molecular players and their interactions.

Main Results:

• Epigenetic and metabolic reprogramming are crucial for BC phenotype.
• Chromatin remodelers influence metabolic pathways like glycolysis and lipogenesis.
• One-carbon metabolism and metabolites (e.g., α-KG, acetyl-CoA, succinate) regulate gene expression via epigenetic modifications.

Conclusions:

• The intricate connection between epigenome, metabolome, and signaling pathways is central to BC.
• Non-invasive biomarkers derived from these interactions hold promise for BC diagnosis, monitoring, and prognosis.
• Further research into these pathways could pave the way for personalized BC therapies.