Expanded Haemodialysis as a Current Strategy to Remove Uremic Toxins

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Surgical Techniques for Catheter Placement and 5/6 Nephrectomy in Murine Models of Peritoneal Dialysis
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Paola Ciceri1, Mario Cozzolino2

  • 1Renal Research Laboratory, Department of Nephrology, Dialysis and Renal Transplant, Fondazione Ca' Granda IRCCS, Ospedale Maggiore Policlinico, 20122 Milan, Italy.

Toxins
|June 2, 2021
PubMed

Insights

Chronic kidney disease (CKD) involves uremic toxin buildup, increasing mortality risk. Targeting these toxins with advanced dialysis techniques like Expanded Hemodialysis (HDx) shows promise for improving patient outcomes and quality of life.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Biomedical Engineering

Background:

  • Chronic kidney disease (CKD) is defined by the accumulation of uremic toxins, which are linked to increased morbidity and mortality.
  • Cardiovascular disease risk is elevated in CKD patients, with uremic toxins implicated as a contributing factor.

Purpose of the Study:

  • To explore the role of uremic toxins in CKD.
  • To review the potential of targeting uremic toxins and their pathways to reduce cardiovascular disease risk.
  • To discuss advancements in dialysis therapies for improved uremic toxin removal.

Main Methods:

  • Literature review of studies on uremic toxins in CKD.
  • Analysis of current and emerging dialysis techniques, including Expanded Hemodialysis (HDx).
  • Examination of the relationship between uremic toxin levels, cardiovascular outcomes, and mortality in CKD.

Main Results:

  • Uremic toxins are key contributors to morbidity and mortality in CKD.
  • Targeting uremic toxins presents a potential strategy for cardiovascular risk reduction in CKD.
  • Improved dialysis membranes and techniques, such as HDx, enhance uremic toxin clearance.

Conclusions:

  • Advances in understanding uremic toxins and dialysis technology offer new therapeutic avenues.
  • Personalized and targeted dialysis treatments can improve clinical outcomes and quality of life for CKD patients.
  • Further research into uremic toxin pathways and novel dialysis strategies is warranted to reduce mortality in CKD.

Keywords:
cardiovascular diseasechronic kidney diseasedialysisuremic toxinsvascular calcification

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