Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mezlocillin in pleural effusions--analysis by HPLC.

J Knöller1, W Schönfeld, M Mayer

  • 1Lehrstuhl für Med. Mikrobiologie und Immunologie, Ruhr-Universität, Bochum.

Zentralblatt Fur Bakteriologie, Mikrobiologie, Und Hygiene. Series A, Medical Microbiology, Infectious Diseases, Virology, Parasitology
|May 1, 1988
PubMed
Summary

This study measured mezlocillin levels in malignant pleural effusions. Mezlocillin reached therapeutic concentrations in pleural fluid, suggesting potential efficacy for treating malignant pleural effusions.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Possible founder effect of rapsyn N88K mutation and identification of novel rapsyn mutations in congenital myasthenic syndromes.

Journal of medical genetics·2003
Same author

Impaired response to insulin associated with protein kinase C in chronic fructose-induced hypertension.

Blood pressure·2003
Same author

Clinical neurokinesiology of spastic gait.

Bratislavske lekarske listy·2002
Same author

Treatment of cluster headache with topiramate: effects and side-effects in five patients.

Cephalalgia : an international journal of headache·2002
Same author

Regulation of cyclooxygenase activity and progesterone production in the rat corpus luteum by inducible nitric oxide synthase.

Reproduction (Cambridge, England)·2002
Same author

Molecular and functional aspects of anionic channels activated during regulatory volume decrease in mammalian cells.

Pflugers Archiv : European journal of physiology·2002

Area of Science:

  • Pharmacology
  • Oncology
  • Clinical Medicine

Background:

  • Malignant pleural effusions are a common complication of cancer.
  • Effective treatment of malignant pleural effusions often requires systemic or local drug delivery.
  • Understanding drug penetration into pleural fluid is crucial for optimizing treatment strategies.

Purpose of the Study:

  • To determine mezlocillin concentrations in pleural fluid of patients with malignant pleural effusions.
  • To evaluate the pharmacokinetic profile of mezlocillin in pleural fluid after intravenous administration.
  • To assess the potential of mezlocillin for treating malignant pleural effusions.

Main Methods:

  • Intravenous infusion of 10 g mezlocillin in six patients with confirmed malignant pleural effusions.

Related Experiment Videos

  • Serial sampling of serum and pleural fluid at multiple time points post-infusion (15 min to 8 h).
  • Quantification of mezlocillin and its metabolites (penicilloic acid, penilloic acid) using high-performance liquid chromatography (HPLC).

    • Main Results:

    • Serum mezlocillin concentrations peaked at 778 +/- 270 micrograms/ml at 15 min, decreasing to 55 +/- 50 micrograms/ml by 8 h.
    • Pleural fluid mezlocillin concentrations reached up to 100 +/- 38 micrograms/ml after 1 hour and were maintained for 7 hours.
    • Metabolite (penicilloic acid) levels were significantly lower in pleural fluid (<1%) compared to serum (2-4%).

    Conclusions:

    • Intravenously administered mezlocillin achieves sustained therapeutic concentrations in malignant pleural effusions.
    • The pharmacokinetic profile suggests mezlocillin may be effective in treating malignant pleural effusions.
    • Further clinical studies are warranted to confirm the efficacy of mezlocillin for this indication.