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Updated: Nov 3, 2025

Ex Vivo Corneal Organ Culture Model for Wound Healing Studies
Published on: February 15, 2019
The Roles of Various Prostaglandins in Fibrosis: A Review
Ke Li1, Jing Zhao1, Mingxuan Wang1
1Department of Ophthalmology, The Second Hospital of Jilin University, Changchun 130000, China.
Abstract:
Organ fibrosis is a common pathological result of various chronic diseases with multiple causes. Fibrosis is characterized by the excessive deposition of extracellular matrix and eventually leads to the destruction of the tissue structure and impaired organ function. Prostaglandins are produced by arachidonic acid through cyclooxygenases and various prostaglandin-specific synthases. Prostaglandins bind to homologous receptors on adjacent tissue cells in an autocrine or paracrine manner and participate in the regulation of a series of physiological or pathological processes, including fibrosis. This review summarizes the properties, synthesis, and degradation of various prostaglandins, as well as the roles of these prostaglandins and their receptors in fibrosis in multiple models to reveal the clinical significance of prostaglandins and their receptors in the treatment of fibrosis.
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