Related Experiment Video

Updated: Nov 3, 2025

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice
05:24

Modeling Ascending Vaginal Infection, Preterm Birth, and Neonatal Morbidity in Mice

Published on: October 10, 2025

79

Preterm Delivery; Who Is at Risk?

Dvora Kluwgant1, Tamar Wainstock2, Eyal Sheiner1

  • 1Soroka University Medical Center, Department of Obstetrics and Gynecology, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva 8400711, Israel.

Journal of Clinical Medicine
|June 2, 2021
PubMed

Insights

Placental abruption is the leading risk factor for extreme preterm birth (PTB). Risk factors for PTB did not significantly differ across various maternal subgroups, including those with multiple gestations or prior PTB.

Area of Science:

  • Obstetrics and Gynecology
  • Neonatal Perinatal Medicine
  • Epidemiology

Background:

  • Preterm birth (PTB) is a primary cause of infant illness and death.
  • Infants born extremely preterm (24-28 weeks gestation) face the most severe health challenges.
  • Identifying risk factors for extreme PTB is crucial for improving neonatal outcomes.

Purpose of the Study:

  • To identify key risk factors associated with extreme preterm birth (PTB).
  • To investigate whether these risk factors vary across different maternal subpopulations, such as those with multiple gestations or a history of PTB.

Main Methods:

  • A population-based retrospective cohort study was conducted.
  • Analyzed data from 334,415 deliveries, focusing on 1155 cases of extreme PTB (24-28 weeks gestation).
  • Examined risk factors in the general population and specific subgroups: multiple gestations, previous PTB, and indicated/induced PTB.

Main Results:

  • Placenta previa (OR=5.8), multiple gestations (OR=7.7), and placental abruption (OR=20.6) were significant risk factors for extreme PTB.
  • Placental abruption emerged as the strongest risk factor across all analyzed groups.
  • Risk factors for extreme PTB showed minimal significant variation among the studied subpopulations.

Conclusions:

  • Placental abruption is a critical risk factor for extreme preterm birth.
  • The identified risk factors for extreme PTB are consistent across various maternal subgroups.
  • Further research into these risk factors may inform targeted interventions to reduce extreme PTB rates.

Keywords:
extreme preterm birthplacental abruptionprematuritypreterm birth

More Related Videos

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats07:36

Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats

Published on: November 20, 2015

11.5K
A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis06:19

A Rat Model of Mild Intrauterine Hypoperfusion with Microcoil Stenosis

Published on: January 7, 2018

10.6K

Related Concept Videos

Factors Affecting the Risk of Infection01:26

Factors Affecting the Risk of Infection

The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
13.0K
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
2.3K
Teratogenicity01:07

Teratogenicity

The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
3.3K
Factors Affecting Illness01:18

Factors Affecting Illness

When a person's physical, emotional, intellectual, social development or spiritual functioning is compromised, this deviation from a healthy normal state is called illness. Illness creates stress that in turn harms individuals. Irritation, anger, denial, hopelessness, and fear are behavioral and emotional changes an individual experiences in the phases of illness. A variety of factors influence a person's health and well-being.
For instance, risk factors are connected to illness,...
4.7K
Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male...
106.7K
Factors Affecting Protein-Drug Binding: Patient-Related Factors01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...
167